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Nature Made SAM-e Complete 400 mg., 60 Tablets


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Estimated delivery: 3-7 days


400 mg. of SAM-e Per Dose

Helps Support a Healthy Mood in as Little as 7–14 Days When Taken Daily

Helps Support Joint Comfort

May Help Support Muscle Comfort and Liver Function

Start By Taking 1 Tablet Daily With Water on an Empty Stomach


Brand: Nature Made

Quantity: 60 Tablets

Supplement Form: Tablet

Product Overview:
Helps support a healthy mood†. Click below to learn more.

Nature Made® SAM-e Complete®** 400 mg can help replenish your SAM-e levels and help support a healthy mood. Nature Made is the #1 best-selling brand of SAM-e supplements. It’s backed by our satisfaction guarantee, and you will receive your money back if you find that it does not work for you.

  • 400 mg of SAM-e (S-adenosylmethionine Tosylate Disulfate)
  • Helps support a healthy mood in as little as 7-14 days when taken daily
  • Helps support joint comfort
  • May help support muscle comfort & liver function
  • #1 Pharmacist Recommended Vitamin & Supplement Brand*
Why should I take SAM-e?

Factors such as age, certain health conditions and poor diet can impact the amount of SAM-e found in the body.

SAM-e, or S-adenosylmethionine, is a compound naturally produced in the body that may increase levels of neurotransmitters, or brain chemicals, responsible for mood.†1 ,2 When levels are low, a SAM-e supplement can help restore the body’s supply of SAM-e.

Therefore, SAM-e is recommended to help support a healthy mood. SAM-e has been shown to work in as little as 7 to 14 days when taken daily as directed. However, if you are experiencing symptoms of a low mood, see a physician for proper guidance.

SAM-e helps support joint comfort.†,3 SAM-e provides a source of dietary sulfur, which plays a role in joint support. Sulfur is a mineral used by the body in connective tissue and joint cartilage.

Drug Interactions

Although generally considered as safe, SAM-e has not been evaluated in children or pregnant or lactating women. People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take any product containing SAM-e except under a doctor's supervision.

SAM-e should not be used when taking St. John's Wort. SAM-e should be used with caution and only under your healthcare provider's supervision when taking MAOI drugs, like Marplan, Nardil, Parnate, Manerix. Individuals on other medications should consult their primary healthcare provider prior to starting SAM-e to check for other potential interactions.

‡ #1 Brand of SAM-e supplements based on POS scan data at Food, Drug, Mass and Club.

** Complete because studies have shown that SAM-e helps support a healthy mood & joint comfort.†

* Based on a survey of pharmacists who recommend branded vitamins and supplements.

Product Dosage/Ingredient Information

Suggested Use: Adults, start by taking 1 tablet daily with water on an empty stomach. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level for you, gradually increase the number of tablets (maximum 1600 mg/day) until benefits are achieved.

Ingredients: S-adenosylmethionine Tosylate Disulfate, Cellulose Gel, Methacrylic Acid Copolymer, Stearic Acid, Silicon Dioxide, Triethyl Citrate, Magnesium Stearate, Color Added, Mannitol, Sodium Starch Glycolate.

CAUTION: People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take any product containing SAM-e except under a physician's supervision. If you are pregnant, nursing, or taking any medications including antidepressants, consult your physician before use.

Foil blister pack ensures safety and freshness. Do not use if tamper evident printed foil seal over tablets is broken.

Store tightly closed, in a cool, dry place, out of reach of children.

For Consumer Questions or Inquiries call 1-800-276-2878 or visit

Why Nature Made?

Nature Made’s Commitment to your Health

Everyone wants a firm foundation to stand upon when making decisions about their health. Since 1971, the Nature Made® brand has been dedicated to supporting your health with a wide range of high quality vitamin supplements. Because of our strong stand on quality and science for more than 40 years, Nature Made has earned recognition and trust among nutrition experts and people just like you.

Safe and Quality Ingredients

Nature Made products are made in accordance with strict Good Manufacturing Practice standards. Nature Made nutrition supplements are made from carefully selected ingredients from trusted suppliers. Nature Made products are guaranteed to meet high quality standards of purity and potency. When you take the vitamins behind that familiar yellow label, know that you’re taking the best for your health.